December 2017

Well, we finally get done with updating our web site, after several months of playing around with it, so we hope you like it!

We have made an excellent rabbit antibody to IBA1 (a.k.a. AIF), RPCA-IBA1. The IBA1 protein is heavily expressed in microglia but not in neurons, astrocytes, oligodendrocytes or other kinds of CNS cell. As a result, antibodies to IBA1 are widely used to identify and study microglia. Microglia are the immune cells of the CNS and appear to have important roles in the cellular responses to a variety of CNS damage and disease states.

We went to the largest Neuroscience meeting in the world, the Society for Neuroscience 2017 meeting in Washington DC, 11th – 15th November. We, along with about 35,000 other nerds, had a great time, lots of interactions with lots of researchers and other companies, and there was a lot of interest in our products. See here for our Facebook report and some images here.

The University of Florida posts on Facebook about one of our customers in the University who makes frequent use of our antibodies. See here.

August 2017

We release several new antibodies to important molecules. We have made a series of antibodies in goat, which have some advantages in terms of cost and reproducibility as we are able to produce very large amounts of antibody consistently. The first is an goat polyclonal antibody to Ki-67, GPCA-Ki67, an excellent marker of dividing cells. We also release a goat antibody to microtubule associated protein 2 (MAP2) GPCA-MAP2, and excellent marker of neurons and their dendritic processes. There is a new goat antibody to 2′-3′-cyclic nucleotide phosphodiesterase (CNP), GPCA-CNP, which is an excellent marker of oligodendrocytes, Schwann cells and myelin sheaths. Then a novel antibody to Fox3/NeuN, and excellent marker of neuronal nuclei GPCA-Fox3. A new antibody to the cytoskeletal protein vimentin GPCA-Vim. Finally there is a novel goat antibody to green fluorescent protein (GFP), GPCA-GFP. Also an excellent mouse monoclonal antibody to the E. coli Trp-E protein, involved in the synthesis of the amino acid tryptophan. This is useful since the pATH series of prokaryotic expression vectors make Trp-E fusion proteins and our antibody can be used to verify that the expressed protein is of the correct molecular size.

January 2017

We hope you are having a Happy New Year! And we release, you guessed, it more antibodies. There is a series of antibodies to the Ki-67 protein, antibodies to which are widely used as cell division and cancer marker. Ki-67 is a large molecule which is essential for the correct segregation of chromosomes during cell division. but is virtually absent from non dividing cells. Presence of the protein, detected by appropriate antibodies, can therefore be used to identify dividing cells in tissues and particularly to identify tumor cells in biopsy and tissue sections. We release two mouse monoclonal antibodies MCA-6G3 and MCA-6B4, a rabbit polyclonal RPCA-Ki67, a chicken polyclonal CPCA-Ki67. All were made against human recombinant protein constructs and all stain dividing human cells in tissue culture and sections cleanly. A goat antibody to the same protein, to be called GPCA-ki67, is in progress and will be available soon.