We release three new antibodies to 2′-3′-cyclic nucleotide phosphodiesterase (CNP), a major protein of oligodendrocytes in the central nervous system. Such antibodies are therefore excellent markers of oligodendrocytes, and, in the peripheral nervous system, Schwann cells. There are two mouse monoclonals MCA-1H10 and MCA-3H5 and a rabbit polyclonal, RPCA-CNP. All work strongly and specifically on […]
Hi, this is the first post in an occasional series which will appear on the EnCor website. It comes out of requests by various individuals who liked to get my writings on various topics, which I was reliably informed were sometimes informative, sometimes amusing and sometimes even accurate. This all grew out of journal clubs […]
We add yet more antibodies and recombinant constructs to our catalog. We release a rabbit polyclonal antibody to total MECP2, RPCA-Mecp2. MECP2 is an important transcription factor with particular activity in the nervous system. We have phosphospecific antibodies of MECP2 under development. We release an rabbit antibody to Green Fluorescent Protein, RPCA-GFP, which can be […]
We release more new antibodies. To complement our calbindin antibodies we now release a new antibody to calretinin. Calbindin and calretinin are small calcium binding proteins which are each found in subsets of neurons in the CNS, and good antibodies to them are therefore useful for the identification of specific neuronal cell types. The new […]
Our immunocytochemical images continue to be used in books, journals and news articles, usually without any attribution, since we did not bother to copyright or watermark any of them. Many have been sent freely to our OEM partners and in some cases to Wikipedia. Scroll down in this very recent high profile on line article […]
We release several new antibodies. These are a new mouse antibody to muscleblind like protein 1, MCA-1H1, and several to Calbindin, made in both mouse MCA-5A9, MCA-4H7 and chicken CPCA-Calb (page in preparation). We also continue to develop a better understanding of all of our current reagents. For example, we previously made antibodies to the […]
We went to the Society for Neuroscience 2014 meeting in Washington DC a few weeks ago, and presented our new antibodies, ELISAs, recombinant proteins and other products, which generated some interest. However the most interest seemed to be directed at our collection of high resolution images which we presented as 24″X36″ posters. We sold some […]
This years Nobel prize in Chemistry is a neat one, for the development of stimulated emission depletion (STED) microscopy. This is basically a modification of the existing confocal fluorescence microscope. Instead of scanning a specimen with a single laser to stimulate a fluorochrome the field is scanned with two lasers simultaneously. The first is the […]
We have had a long time interest in the intermediate or 10nm filaments of the nervous system, antibodies to which are very useful cell type and developmental markers. There has also been considerable recent interest in the detection of these proteins as biomarkers of different kinds of CNS damage and disease. In the last few […]
A few months ago we made some mouse monoclonal antibodies to the interesting cell division and cancer related Aurora A, a highly conserved serine/threonine protein kinase. These seemed to work very well but we subsequently found that some of them cross-reacted with the very closely related Aurora B. We therefore went to the trouble of […]
