We finally get done with updating our web site, after several months of playing around with it, so we hope you like it! We have made an excellent rabbit polyclonal antibody to IBA1 (a.k.a. AIF1), RPCA-IBA1. The IBA1 protein is heavily expressed in microglia but not in neurons, astrocytes, oligodendrocytes or other kinds of CNS […]
We went to the largest Neuroscience meeting in the world, the Society for Neuroscience 2017 meeting in Washington DC, 11th – 15th November. We, along with about 35,000 other nerds, had a great time, lots of interactions with lots of researchers and other companies, and there was a lot of interest in our products. See […]
We release several new antibodies to important molecules. We have made a series of antibodies in goat, which have some advantages in terms of cost and reproducibility as we are able to produce very large amounts of antibody consistently. The first is an goat polyclonal antibody to Ki-67, GPCA-Ki67, an excellent marker of dividing cells. […]
We release new mouse monoclonal antibodies to MECP2, the methyl CpG binding protein 2. This is an important transcriptional regulator of neurons sequence defects in which are associated with Rett syndrome, a serious neurodevelopmental disorder. These are the IgG2b MCA-5H12 and the IgG1 MCA-4E11. We release an excellent chicken antibody to the neural stem cell marker […]
We release two more Cas9/CRISPR related antibodies, a rabbit polyclonal to Streptococcus pyogenes Cas9, RPCA-Cas9-AP and a mouse monoclonal, MCA-3F9 to the same protein. These can be used to confirm the expression of the most commonly used Cas9 molecule in transfection experiments.
We continue to release antibodies to Cas9, the key enzyme in the CRISPR gene editing system. These are RPCA-Cas9-SA and CPCA-Cas9-SA. These polyclonal antibodies recognize the Cas9 protein from Staphylococcus aureus, which is considerably smaller than the Streptococcus pyogenes derived Cas9. Since the two Cas9 enzymes are quite different in amino acid sequence our antibody […]
The life sciences have recently been revolutionized by the exploitation of the bacterial CRISPR system. CRISPR is an acronym for “Clustered Regularly Interspaced Short Palindromic Repeats”. The short palindromes are DNA sequences generated by the bacterial host, while the DNA inserts between them are derived from infectious agents which have previously challenged the bacteria. These […]
Happy New Year and all that!! We release several more novel immunoreagents. There are no less than 6 different antibodies to complement C3 made against specific subdomains of this important molecule. Three were made against a recombinant form of the netrin domain of human C3 which is at the C-terminus of the α-chain. These are […]
We add two antibodies to the Heat Shock 60 (HSP60) protein, a major component of the mitochondrial membrane. These are the mouse monoclonal MCA-1C7 and a rabbit polyclonal RPCA-HSP60. Both are very clean and specific on western blots of crude extracts of cells and tissues and both stain mitochondria beautifully, as shown here. We release […]
We release a novel mouse monoclonal antibody specific for microtubule associated protein 2D (MAP2D), MCA-2C4. This was raised against the purified recombinant human MAP2D, an embryonic form of this major CNS molecule. Our experiments show that this antibody also binds to MAP2C, the smallest product from the MAP2 gene. The antibody therefore will stain all […]
