September 2018 News

We release yet more antibodies! While we were upgrading our website quite a backlog built up, so we are releasing an unusual number of new reagents this month. We previously generated a rabbit polyclonal antibody to adenylate cyclase III (ACIII), RPCA-ACIII, which is an excellent marker of neuronal cilia in human and rodent cells and tissues. We now release two new reagents which are also good neuronal cilia markers, specifically mouse monoclonal antibody to ACIII MCA-1A12 and chicken polyclonal antibody to ACIII CPCA-ACIII. These were made against the same ACIII peptide as our original rabbit antibody, which has become widely used, and have very similar properties and so will complement the rabbit antibody. We improved our western blotting and immunofluorescence data for our antibody to the product of the Ewing’s sarcoma breakpoint 1 EWSR1 gene, the EWS protein, antibody MCA-5H7. We also have additional data for our mouse monoclonals to methyl-CpG binding protein 2 (MeCP2), MCA-4F11 and MCA-5H12. There is a new antibody to the RNA binding protein FOX2, CPCA-FOX2 made in chicken, which specifically binds the nuclei of neurons many of which are not recognized by antibodies to NeuN, now known to correspond to a close relative of FOX2, namely FOX3. There is also a new rabbit polyclonal antibody to the serotonin transporter RPCA-SERT, a useful marker of serotinergic neurons and their thin beaded processes. A new rabbit polyclonal antibody to fibrillarin RPCA-Fib, an excellent marker of nucleoli to complement our widely used mouse and chicken antibodies to the same protein. Also new antibodies to myristoylated alanine rich C-kinase substrate (MARCKS), a chicken polyclonal CPCA-MARCKS and a mouse monoclonal MCA-5F9.